Wedeen The Geometric Structure of the Brain Fiber Pathways
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منابع مشابه
Response to comment on "the geometric structure of the brain fiber pathways".
In response to Catani et al., we show that corticospinal pathways adhere via sharp turns to two local grid orientations; that our studies have three times the diffusion resolution of those compared; and that the noted technical concerns, including crossing angles, do not challenge the evidence of mathematically specific geometric structure. Thus, the geometric thesis gives the best account of t...
متن کاملComment on "The geometric structure of the brain fiber pathways".
Wedeen et al. (Reports, 30 March 2012, p. 1628) proposed a geometrical grid pattern in the brain that could help the understanding of the brain's organization and connectivity. We show that whole-brain fiber crossing quantification does not support their theory. Our results suggest that the grid pattern is most likely an artifact attributable to the limitations of their method.
متن کاملThe geometric structure of the brain fiber pathways.
The structure of the brain as a product of morphogenesis is difficult to reconcile with the observed complexity of cerebral connectivity. We therefore analyzed relationships of adjacency and crossing between cerebral fiber pathways in four nonhuman primate species and in humans by using diffusion magnetic resonance imaging. The cerebral fiber pathways formed a rectilinear three-dimensional grid...
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Brain fiber pathways are presumed to follow smooth curves but recent high angular resolution diffusion MRI (dMRI) suggests that instead they follow 3 primary axes often nearly orthogonal. To investigate this, we analyzed axon pathways under monkey primary motor cortex with (1) dMRI tractography, (2) axon tract tracing, and (3) axon immunohistochemistry. dMRI tractography shows the predicted cro...
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